2018年1月8日(星期一)吉林大学外专千人Myongsoo Lee教授学术报告

报告主题:Dynamic Self-Assembly for Life-inspired Systems

报告人:Myongsoo Lee教授 吉林大学外专千人 韩国科学院院士

主持人:黄哲钢教授

时间:2018年1月8日(星期一)上午:10:00

地点:丰盛堂芙兰学术中心A402

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报告摘要:

Inspired by nature, we have elaborated how to construct dynamic self-assembled nanostructures exhibiting switchable functions. For example, synthetic tubular pores are able to undergo open-closed switching driven by an external signal. The pore-switching mediates a water pumping action for the dehydrative cyclization of AMP nucleotide. When self-assembled tubules embed DNA inside the hollow cavities, the chirality of DNA is able to transfer accurately to the coat assembly. The DNA-coat assembly undergoes simultaneous helicity switching in physiological conditions. In the case of toroid assembly, the discrete toroids are able to reversibly propagate in a helical sense by nucleating with an activator through allosteric switching, similar to TMV virus coat assembly. Moving from 1-D to 2-D structures, the internal pores are able to form chiral interior which selectively capture one enantiomer in racemic solution with perfect pore performance. Remarkably, the pores are closed with simultaneous pumping of the captured molecules driven by environmental changes. I will discuss recently discovered these results with their biological implications.   

报告人简介:

Myongsoo Lee教授1960年出生于韩国忠清南道。师从Virgil Percec, 1992年在凯斯西储大学拿到博士学位。是Chem. Asian Journal, Journal of Ploymer Science-Polymer Chemistry, Macromolecular Research等国际期刊的编委,日本学术振兴会委员。Myongsoo Lee教授是超分子纳米组装创新研究中心的学术带头人。主要针对构筑多组分分子体系为出发点,研究复合体系的协同组装(包括溶液、界面及固相组装)及组装规律,组装结构与性能的关系。已在Science, Nature, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., 等国内外学术刊物上发表论文210篇,迄今为止论文被他人引用6000多次,H-index52。先后获得过韩国高分子科学奖、Wiley的“杰出青年科学家奖”、延世学术奖、韩国科学奖、三星高分子科学奖、韩国化学奖、教育部长江学者奖励计划“讲座教授”、中组部外专千人,2007年入选韩国科学院院士。

 

最近发表的论文

[1] Y. Kim, H. Li, X. Chen, X. Ma, M. Lee, Nature Nanotech. 2017, 12, 551

[2] B. Shen, Y. He, Y. Kim, Y. Wang, M. Lee, Angew. Chem. Int. Ed. 2016, 55, 2382.

[3] X. Chen, Y. He, Y. Kim, M. Lee, J. Am. Chem. Soc. 2016, 138, 5773.

[4] Y. Wang, Y. Kim, M. Lee, Angew. Chem. Int. Ed. 2016, 128, 13316

[5] Y. Kim, J. Kang, B. Shen, Y. Wang, Y. He, M. Lee, Nature Commun. 2015, 6, 8650.

[6] Z. Huang, S.-K. Kang, M. Banno, T. Yamaguchi, D. Lee, C. Seok, E. Yashima, M. Lee

      Science 2012, 337, 1521-1526.


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